منابع مشابه
eIF2 activated in spots
An actin ruler n page 947, McElhinny et al. suggest that nebulin is a molecular ruler for actin filaments in muscle cells. Muscle physiology depends on the precise alignment, length, and overlap of thin (actin) and thick (myosin) filaments. Capping proteins such as Tmod stop the growing and shrinking of dynamic thin filaments but lack the innate ability to know when to do so. The new results sh...
متن کاملThe absence of nuclear eIF2
Eukaryotic translation initiation factor 2 (eIF2) is necessary for binding of the methionyl-tRNA to the small ribosomal subunit and therefore is essential to the commencement of protein translation. It is of particular interest since it is a site of regulation of protein synthesis. Phosphorylation of its α subunit by a family of stress-dependent kinases leads to rapid inhibition of protein synt...
متن کاملIntegrating Sustainable Hunting in Biodiversity Protection in Central Africa: Hot Spots, Weak Spots, and Strong Spots
Wild animals are a primary source of protein (bushmeat) for people living in or near tropical forests. Ideally, the effect of bushmeat harvests should be monitored closely by making regular estimates of offtake rate and size of stock available for exploitation. However, in practice, this is possible in very few situations because it requires both of these aspects to be readily measurable, and e...
متن کاملSpots
Fas (CD95, APO-1, TNFRSF6) is a TNF receptor superfamily member that directly triggers apoptosis and contributes to the maintenance of lymphocyte homeostasis and prevention of autoimmunity. Although FADD and caspase-8 have been identified as key intracellular mediators of Fas signaling, it is not clear how recruitment of these proteins to the Fas death domain leads to activation of caspase-8 in...
متن کاملTransitional-turbulent spots and turbulent-turbulent spots in boundary layers.
Two observations drawn from a thoroughly validated direct numerical simulation of the canonical spatially developing, zero-pressure gradient, smooth, flat-plate boundary layer are presented here. The first is that, for bypass transition in the narrow sense defined herein, we found that the transitional-turbulent spot inception mechanism is analogous to the secondary instability of boundary-laye...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1706iti3